Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis.
Identifieur interne : 000984 ( Main/Exploration ); précédent : 000983; suivant : 000985Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis.
Auteurs : Sang-Nee Tan [Malaisie] ; Sai-Peng Sim [Malaisie] ; Alan S B. Khoo [Malaisie]Source :
- BMC molecular biology [ 1471-2199 ] ; 2018.
Descripteurs français
- KwdFr :
- Analyse de séquence d'ADN, Apoptose (), Apoptose (génétique), Cassure de chromosome, Cellules épithéliales (métabolisme), Humains, Lignée cellulaire, Muqueuse respiratoire (cytologie), Muqueuse respiratoire (métabolisme), Peroxyde d'hydrogène (métabolisme), Peroxyde d'hydrogène (pharmacologie), Régions d'ancrage à la matrice nucléaire (génétique), Stress oxydatif, Séquence nucléotidique.
- MESH :
- cytologie : Muqueuse respiratoire.
- génétique : Apoptose, Régions d'ancrage à la matrice nucléaire.
- métabolisme : Cellules épithéliales, Muqueuse respiratoire, Peroxyde d'hydrogène.
- pharmacologie : Peroxyde d'hydrogène.
- Analyse de séquence d'ADN, Apoptose, Cassure de chromosome, Humains, Lignée cellulaire, Stress oxydatif, Séquence nucléotidique.
English descriptors
- KwdEn :
- Apoptosis (drug effects), Apoptosis (genetics), Base Sequence, Cell Line, Chromosome Breakage, Epithelial Cells (metabolism), Humans, Hydrogen Peroxide (metabolism), Hydrogen Peroxide (pharmacology), Matrix Attachment Regions (genetics), Oxidative Stress, Respiratory Mucosa (cytology), Respiratory Mucosa (metabolism), Sequence Analysis, DNA.
- MESH :
- chemical , metabolism : Hydrogen Peroxide.
- cytology : Respiratory Mucosa.
- drug effects : Apoptosis.
- genetics : Apoptosis, Matrix Attachment Regions.
- metabolism : Epithelial Cells, Respiratory Mucosa.
- chemical , pharmacology : Hydrogen Peroxide.
- Base Sequence, Cell Line, Chromosome Breakage, Humans, Oxidative Stress, Sequence Analysis, DNA.
Abstract
Oxidative stress is known to be involved in most of the aetiological factors of nasopharyngeal carcinoma (NPC). Cells that are under oxidative stress may undergo apoptosis. We have previously demonstrated that oxidative stress-induced apoptosis could be a potential mechanism mediating chromosome breakages in nasopharyngeal epithelial cells. Additionally, caspase-activated DNase (CAD) may be the vital player in mediating the chromosomal breakages during oxidative stress-induced apoptosis. Chromosomal breakage occurs during apoptosis and chromosome rearrangement. Chromosomal breakages tend to cluster in certain regions, such as matrix association region/scaffold attachment region (MAR/SAR). We hypothesised that oxidative stress-induced apoptosis may result in chromosome breaks preferentially at the MAR/SAR sites. The AF9 gene at 9p22 was targeted in this study because 9p22 is a deletion site commonly found in NPC.
DOI: 10.1186/s12867-018-0116-5
PubMed: 30514321
Affiliations:
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Cells that are under oxidative stress may undergo apoptosis. We have previously demonstrated that oxidative stress-induced apoptosis could be a potential mechanism mediating chromosome breakages in nasopharyngeal epithelial cells. Additionally, caspase-activated DNase (CAD) may be the vital player in mediating the chromosomal breakages during oxidative stress-induced apoptosis. Chromosomal breakage occurs during apoptosis and chromosome rearrangement. Chromosomal breakages tend to cluster in certain regions, such as matrix association region/scaffold attachment region (MAR/SAR). We hypothesised that oxidative stress-induced apoptosis may result in chromosome breaks preferentially at the MAR/SAR sites. The AF9 gene at 9p22 was targeted in this study because 9p22 is a deletion site commonly found in NPC.</div></front></TEI><affiliations><list><country><li>Malaisie</li></country></list><tree><country name="Malaisie"><noRegion><name sortKey="Tan, Sang Nee" sort="Tan, Sang Nee" uniqKey="Tan S" first="Sang-Nee" last="Tan">Sang-Nee Tan</name></noRegion><name sortKey="Khoo, Alan S B" sort="Khoo, Alan S B" uniqKey="Khoo A" first="Alan S B" last="Khoo">Alan S B. Khoo</name><name sortKey="Sim, Sai Peng" sort="Sim, Sai Peng" uniqKey="Sim S" first="Sai-Peng" last="Sim">Sai-Peng Sim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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